YAO Ji-wen,LI Bo,ZHANG Xuan,et al.Study on Relationship between TCM Syndromes of T2DM with Lower Extremity Arterial Disease and Intracranial Arterial Stenosis[J].Chinese Journal of Library and Information Science for Traditional Chinese Medicine,2016,40(3):16-19.[doi:10.3969/j.issn.2095-5707.2016.03.004]
2型糖尿病中医证型与下肢动脉病及颅内动脉狭窄关系研究
- Title:
- Study on Relationship between TCM Syndromes of T2DM with Lower Extremity Arterial Disease and Intracranial Arterial Stenosis
- 文章编号:
- 2095-5707(2016)03-0016-04
- Keywords:
- type 2 diabetes (T2DM); lower extremity arterial disease; intracranial arterial stenosis; TCM syndrome; integrated traditional Chinese and Western medicine
- 分类号:
- R255.4
- 文献标志码:
- A
- 摘要:
- 目的 探讨2型糖尿病中医证型与下肢动脉病及颅内动脉狭窄的关系。方法 对2013年2－8月我院住院及门诊的139例2型糖尿病患者进行中医辨证分型，选取正常体检者25例作为正常对照组，分析中医不同证型与下肢动脉病及颅内动脉狭窄的关系。结果 ⑴气阴两虚型和阴阳两虚型的糖尿病病程较湿热困脾型和阴虚热盛型更长；⑵湿热困脾型、阴虚热盛型、气阴两虚型、阴阳两虚型患者的踝臂指数（ABI）值依次递减，说明狭窄程度趋于严重；⑶所有患者中，气阴两虚型和阴阳两虚型发生颅内动脉狭窄的比例最高，分别为18.7%、12.9%；35例阴阳两虚型患者中，颅内动脉狭窄发生率占该证型的51.4%，高于其他3个证型。结论 气阴两虚型和阴阳两虚型更易发生下肢动脉病和颅内动脉狭窄。中西医结合筛查可显著延迟或预防2型糖尿病高危人群（阴阳两虚型和气阴两虚型患者）颅内动脉狭窄和下肢动脉病的发生。
- Abstract:
- Objective To discuss the relationship between TCM syndromes of type 2 diabetes (T2DM) with lower extremity arterial disease and intracranial arterial stenosis. Methods From February 2013 to August, 139 hospitalized patients and outpatients with T2DM were studied for TCM syndrome differentiation. 25 normal subjects were chosen as normal control group. Relationship between TCM different syndromes with lower extremity arterial disease and cranial artery stenosis was analyzed. Results (1) The duration of diabetes of qi-yin deficiency type and yin-yang deficiency type were longer than types of damp heat in the spleen and yin deficiency and excessive heat; ⑵ ABI value was in descending order: damp heat in the spleen typr, yin deficiency type and excessive heat type, qi-yin deficiency type and yin-yang deficiency type, indicating the more severe stenosis; ⑶ Among all the patients, the incidence for intracranial arterial stenosis in qi-yin deficiency type (18.7%) and yin-yang deficiency (12.9%) was the highest; among the 35 cases of yin-yang deficiency type, the incidence of intracranial arterial stenosis occupied 51.4%, higher than the other three types. Conclusion Qi-yin deficiency type and yin-yang deficiency type are more likely to lead to lower extremity arterial disease and intracranial arterial stenosis. Integrated traditional Chinese and Western medicine combining screening can significantly delay or prevent T2DM in high-risk population (qi-yin deficiency type and yin-yang deficiency type).
参考文献/References:
[1] WHO. Global status report on noncommunicable diseases 2014[EB/OL].[2016-03-01].http://www.who.int/nmh/publications/ ncd-status-report-2014/en/.
[2] Yang WY, LU JM, WENG JP, et al. Prevalence of diabetes among men and women in China[J]. N ENGL J Med,2010(12):1090-1101.
[3] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[4] 中华中医药学会.糖尿病中医防治指南糖尿病合并脑血管病[J].中国中医药现代远程教育,2011,9(19):138-140.
[5] WHO. Definition, diagnosis and classifications of diabetes mellitus and its complications[R]// Report of a WHO consultation, Part 1: Diagnosis and classification of diabetes mellitus. Geneva: WHO,1999:31-33.
[6] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:233-234.
[7] TSIVGOULIS G, ALEXANDROV AV, SLOAN MA. Advances in transcranial doppler ultrasonography[J]. Curr Neurol& Neurosci Rep,2009,9(1):46-54.
[8] RESNICK HE, LINDSAY RS, MCDERMOTT MM, et al. Relationship of high and low ankle brachial index to all-cause and cardiovascular disease mortality: the strong heart study[J]. Circulation,2004(6):737-739.
备注/Memo
收稿日期：2016-03-13
更新日期/Last Update:
2016-05-23