基于利水功效组群药物的中药药性规律研究

Title:

A Study on Regularity of the Property of Chinese Materia Medica Based on Group Drugs with Diuretic Efficacy

作者:

史磊¹; 曹思思²

1.黑龙江中医药大学图书馆，黑龙江 哈尔滨 150040；2.哈尔滨职业技术学院，黑龙江 哈尔滨 150081

Author(s):

Shi Lei¹;  Cao Sisi²

1. Library of Heilongjiang University of Chinese Medicine, Harbin Heilongjiang 150040, China; 2. Harbin Vocational and Technical College, Harbin Heilongjiang 150081, China

关键词:

利水功效; 组群药物; 中药; 药性规律

Keywords:

diuretic efficacy;  group drugs;  Chinese materia medica;  regularity of the property of medicine

DOI:

10.3969/j.issn.2095-5707.2014.04.003

文献标志码:

A

摘要:

目的 探讨利水药物的药性规律，旨在为利水药物药性理论的现代研究和临床筛选使用利水药物提供借鉴。方法 从《中华本草》、《现代中药学大辞典》和《中药原植物化学成分集》中选取有明显利水功效的临床常用中药35味，建立利水功效组群中药数据集，运用文献学和现代统计学相融合的研究方法，对其科属、四气、五味、归经、毒性、功效、主治、有效成分进行统计分析与归纳。结果 35味利水功效组群药物中，药性分析以寒性为主要偏性，占71.42%；药味分析排在前两位的依次是苦味（60.00%）、甘味（54.29%）；归经排在前两位的依次是归肺经（51.43%）、归肾经（40.00%）；毒性分析仅牵牛子、商陆、香加皮3味药有毒性；功效主治分析排在前四位的依次是利水消肿、解毒、清热生津止渴、通淋；有效成分物质基础主要为黄酮类化合物（28.57%）和甾体类化合物（25.71%）。结论 初步探讨出利水功效组群中药的药性规律，为中药药性理论体系的现代化研究提供有益借鉴。

Abstract:

Objective The article is aimed at discussing regularity of the property of diuretic Chinese materia medica and providing reference for modern researches on diuretic Chinese materia medica and selection of clinical treatment. Methods This article established the dataset of group drugs with diuretic efficacy by selecting 35 commonly-used clinical ingredients from Chinese Materia Medica, Dictionary of Modern Chinese Medicine and Chemical Components of Source Plants in Traditional Chinese Medicine. It statistically analyzed and summarized the genus, four properties, five tastes, channel tropism, toxicity, efficiency, major functions and active ingredients by using the research method of combination of philology and modern statistics. Results In the property of drugs, cold, as the main bias, occupied the largest proportion of the 35 group drugs with diuretic efficacy 71.42%. In the flavor of drugs, the largest proportions were bitter 60.00% and sweet 54.29%. In channel tropism analysis, the first two were lung channel 51.43% and kidney channel 40.00%. In toxicity analysis, only Semen Pharbitidis, Radix Phytolaccae and Cortex Periplocae were toxic. The most significant effects in efficacy and major functions analysis were as follows: the first was inducing diuresis and alleviating edema; the second was detoxification; the third was clearing heat and helping produce saliva and slake thirst; the last one was treating stranguria. The main substance bases of the active ingredients were flavanoid (28.57%) and steroidal compounds (25.71%). Conclusion This article made a preliminary exploration on regularity of the property of group drugs with diuretic efficacy and provided reference for the modern researches on the theoretical system of property of Chinese materia medica.